A rescue source said one of the wounded men was wearing the Rangers’ uniform whereas the other was dressed in plain clothes.
The wounded were shifted to PNS Shifa hospital for treatment.
A Rangers’ spokesman said the explosion had targeted a wing commander of the force who was travelling in the vehicle. He added that body parts, including a head and legs, were found from the site which suggested that the explosion was carried out by a suicide bomber.
The body parts were sent to Jinnah Hospital for analysis and identification.
The targeted vehicle was partially damaged in the blast which was heard from far distances.
Police and Rangers’ personnel reached the blast site and cordoned off the area as a probe into the incident went underway.
Earlier during the day, Rangers’ personnel had conducted targeted operations in Mullah Essa Goth in the city’s Sohrab Goth and Surjani Town’s Sector 5-E areas during which several suspects were taken into custody.
Around 800 Rangers’ personnel, including women, took part in the operations.
A number of weapons and ammunition were also recovered from the arrested suspects.