Eyewitnesses stated that a number of settlers, of the Karmie Shomron illegal settlement, attacked the car causing the driver to lose control before the vehicle crashed and flipped over.
The three wounded Palestinians have been identified as Abdul-Qader Hussein Samhan, Mohamad Abdullah Omran, and Mohammad Ahmad Hussein.
They were moved to the Darwish Nazzal Governmental hospital in Qalqilia.
Several settler attacks have also been reported in different parts of the occupied West Bank.
In the Gaza Strip, Israeli navy boats opened fire at several Palestinian fishing boats, near the Gaza City shore, causing extensive damage but no injuries.