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Palestine: Three Palestinians killed, incl 3 year-old child, in Israeli airstrikes on Gaza City

Palestine: Dozens Palestinians abducted by Israeli forces in West Bank, Jerusalem

Palestine: Israeli army demolishes cave housing family near Bethlehem

Palestine: Several Palestinians kidnapped by Israeli forces in West Bank, Israeli settlers attack cars

Palestine: Israel bombs Gaza, withdraws negotiators from Cairo

Pakistan: 18 suspected militants killed in fresh NWA, Khyber airstrikes

US: Ferguson curfew lifted, Obama appeals for restraint

Iraq: Obama says Mosul Dam retaken from extremists with US help

Palestine: Palestinian female detainee denied family visits since her arrest in 2012

Palestine: Nine Palestinians kidnapped by Israeli soldiers from West Bank, Jerusalem

Palestine: Israeli army detonates two homes in Hebron, seals one with concrete blocs

Palestine: Six Palestinians kidnapped by Israeli forces in West Bank

Syria: Airstrikes kill 31 terrorists in Raqqa city

Palestine: Body recovered in Shujaiyya a month after ‘massacre’ by Israel

Palestine: Hamas says Israel stalling on agreement as Gaza death toll hits 2016

US: Curfew imposed for second night in Ferguson, Missouri

Palestine: Palestinian arrested filming Israeli settlers throwing stones in W Bank

Israel: 5 of 64 Israeli soldiers killed in Gaza invasion were killed by ‘Friendly Fire’

UK: Healthy baby born from new IVF gene screening technique

8th Jul 2013

Scientists meeting in London have announced the birth of the first baby to come from a new IVF technique that screens embryos for genetic defects. It is hoped the method could improve the low overall IVF success rate.

The baby boy was born in June in the US state of Pennsylvania, with a second woman who underwent the screening process due to give birth shortly.

The technique, known as next generation sequencing or NGS, uses low-cost modern DNA sequencing to reveal inherited genetic disorders, chromosome abnormalities, defects and mutations, before the embryo is implanted into the womb.

In-vitro fertilization, when eggs are fertilized with sperm in a laboratory, has a relatively low pregnancy success rate after implantation – around 30 percent. While it’s not known why the failure rate is so high, genetic defects are high on the list of suspects, according to the authors of research being presented on Monday at the annual meeting of the European Society of Human Reproduction and Embryology (ESHRE).

“Many of the embryos produced during infertility treatments have no chance of becoming a baby because they carry lethal genetic abnormalities,” said study author Dagan Wells, from the University of Oxford’s NIHR Biomedical Research Center.

“Next generation sequencing improves our ability to detect these abnormalities and helps us identify the embryos with the best chances of producing a viable pregnancy,” Wells said.

ESHRE says one in six couples worldwide experience some form of infertility problem at least once in their lifetime.

In addition, the new technique could be significantly cheaper than current technology and yield more genetic data than older methods.

“We can do this at a cost which is about a half to two-thirds of what current chromosome screening costs are,” said Wells.

“If further randomized trials confirm this, we could reach a point where there is a very strong economic argument that this should be offered very widely – perhaps to the majority of IVF patients.”

According to Wells, the method has started to be used in genetic research and diagnostics, but not in embryo screening.

He said that current methods to detect gene deficiencies in embryos added more than £2,000 (2,300 euros, $3,000) to a single IVF attempt.

“The new method should allow costs to be reduced by several hundred pounds, potentially bringing the benefits of chromosome screening within the reach of a far greater number of patients,” said Wells, describing how he tested the technique on an “abnormally high” number of embryos until he was satisfied of a high level of accuracy.

A randomized clinical trial is due to begin later this year to determine the technique’s efficacy.

jr/ccp (Reuters, AFP)

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